Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis.

@article{Sabiiti2014EfficientPA,
  title={Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis.},
  author={Wilber Sabiiti and Emma Robertson and Mathew A Beale and Simon Andrew Johnston and Annemarie E. Brouwer and Angela Loyse and Joseph Nicholas Jarvis and Andrew S Gilbert and Matthew C. Fisher and Thomas Stephen Harrison and Robin C May and Tihana A Bicanic},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 5},
  pages={2000-8}
}
BACKGROUND Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality globally. High fungal burden in cerebrospinal fluid (CSF) at diagnosis and poor fungal clearance during treatment are recognized adverse prognostic markers; however, the underlying pathogenic factors that drive these clinical manifestations are incompletely understood. We profiled a large set of clinical isolates for established cryptococcal virulence traits to evaluate the contribution of C. neoformans… CONTINUE READING
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