Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis.

  title={Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis.},
  author={Wilber Sabiiti and Emma Robertson and Mathew A Beale and Simon Andrew Johnston and Annemarie E. Brouwer and Angela Loyse and Joseph Nicholas Jarvis and Andrew S Gilbert and Matthew C. Fisher and Thomas Stephen Harrison and Robin C May and Tihana A Bicanic},
  journal={The Journal of clinical investigation},
  volume={124 5},
BACKGROUND Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality globally. High fungal burden in cerebrospinal fluid (CSF) at diagnosis and poor fungal clearance during treatment are recognized adverse prognostic markers; however, the underlying pathogenic factors that drive these clinical manifestations are incompletely understood. We profiled a large set of clinical isolates for established cryptococcal virulence traits to evaluate the contribution of C. neoformans… CONTINUE READING
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Publications referenced by this paper.
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The phenotype of the Cryptococcus-specific CD4+ memory T-cell response is associated with disease severity and outcome in HIV-associated cryptococcal meningitis

JN Jarvis
J Infect Dis • 2013
View 9 Excerpts
Highly Influenced

IFN- at the site of infection determines rate of clearance of infection in cryptococcal meningitis

AA Siddiqui
J Immunol • 2005
View 9 Excerpts
Highly Influenced

Fc receptor 3A polymorphism and risk for HIV-associated cryptococcal disease

S Rohatgi
MBio • 2013
View 2 Excerpts

Fc γ receptor 3 A polymorphism and risk for HIV - associated cryptococcal disease

H Ma, JE Croudace, DA Lammas, RC May
MBio • 2013

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