Efficient pattern comparative method for selecting functionally important motifs in protein sequences: application to zinc enzymes.

Abstract

We have developed a pattern comparative method for identifying functionally important motifs in protein sequences. The essence of most standard pattern comparative methods is a comparison of patterns occurring in different sequences using an optimized weight matrix. In contrast, our approach is based on a measure of similarity among all the candidate motifs within the same sequence. This method may prove to be particularly efficient for proteins encoding the same biochemical function, but with different primary sequences, and when tertiary structure information from one or more sequences is available. We have applied this method to a special class of zinc-binding enzymes known as endopeptidases.

Cite this paper

@article{Kister1993EfficientPC, title={Efficient pattern comparative method for selecting functionally important motifs in protein sequences: application to zinc enzymes.}, author={Alexander Kister and Ilya Muchnik and Djamal Bouzida and E. L. Reinherz and Theodore F. Smith}, journal={Bio Systems}, year={1993}, volume={30 1-3}, pages={233-40} }