Efficient one-pot, two-step, microwave-assisted procedure for the synthesis of polysubstituted 2-aminoimidazoles.

@article{Ermolatev2006EfficientOT,
  title={Efficient one-pot, two-step, microwave-assisted procedure for the synthesis of polysubstituted 2-aminoimidazoles.},
  author={Denis S. Ermolat'ev and Eugene V. Babaev and Erik V Van der Eycken},
  journal={Organic letters},
  year={2006},
  volume={8 25},
  pages={5781-4}
}
A microwave-assisted, one-pot, two-step protocol was developed for the construction of polysubstituted 2-aminoimidazoles. This process involves the sequential formation of imidazo[1,2-a]pyrimidinium salts from readily available 2-aminopyrimidines and alpha-bromocarbonyl compounds, followed by opening of the pyrimidine ring with hydrazine. [reaction: see text]