Efficient multiple genome alignment

  title={Efficient multiple genome alignment},
  author={Michael H{\"o}hl and Stefan Kurtz and Enno Ohlebusch},
  volume={18 Suppl 1},
MOTIVATION To allow a direct comparison of the genomic DNA sequences of sufficiently similar organisms, there is an urgent need for software tools that can align more than two genomic sequences. RESULTS We developed new algorithms and a software tool 'Multiple Genome Aligner' (MGA for short) that efficiently computes multiple genome alignments of large, closely related DNA sequences. For example, it can align 85% percent of the complete genomes of six human adenoviruses (average length 35305… CONTINUE READING
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