Efficient metal-ion catalyzed template-directed oligonucleotide synthesis.

@article{Lohrmann1980EfficientMC,
  title={Efficient metal-ion catalyzed template-directed oligonucleotide synthesis.},
  author={R. Lohrmann and P. Bridson and L. Orgel},
  journal={Science},
  year={1980},
  volume={208 4451},
  pages={
          1464-5
        }
}
The Pb2+ and Zn2+ ions are efficient catalysts for the polycytidylic acid-directed polymerization of an activated guanylic acid derivative, guanosine 5'-phosphorimidazolide. The products include oligomers of 30 to 40 units in length. The nucleotide residues are predominantly 2'-5' linked when Pb2+ is the catalyst, and predominantly 3'-5' linked in the presence of Zn2+. The significance of these results in the context of the prebiotic evolution of RNA polymerase is discussed. 
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