Efficient maximum likelihood pedigree reconstruction.

  title={Efficient maximum likelihood pedigree reconstruction.},
  author={Robert G. Cowell},
  journal={Theoretical population biology},
  volume={76 4},
A simple and efficient algorithm is presented for finding a maximum likelihood pedigree using microsatellite (STR) genotype information on a complete sample of related individuals. The computational complexity of the algorithm is at worst (O(n(3)2(n))), where n is the number of individuals. Thus it is possible to exhaustively search the space of all pedigrees of up to thirty individuals for one that maximizes the likelihood. A priori age and sex information can be used if available, but is not… CONTINUE READING
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