Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector.

@article{Xiao1996EfficientLG,
  title={Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector.},
  author={Xiao Xiao and Juan Li and Richard Jude Samulski},
  journal={Journal of virology},
  year={1996},
  volume={70 11},
  pages={8098-108}
}
Muscle-directed gene transfer is being considered for the treatment of several metabolic diseases, including hemophilia and Duchene's muscular dystrophy. Previous efforts to target this tissue for somatic delivery with various vector systems have resulted in transient expression due to silencing of the transgene or to an immune response against the vector-transduced cells. We introduced recombinant adeno-associated virus vector (rAAV) carrying a lacZ reporter into muscle tissue of… CONTINUE READING

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