Efficient killing of chronic B-lymphocytic leukemia cells by superantigen-directed T cells.

@article{Wallgren1993EfficientKO,
  title={Efficient killing of chronic B-lymphocytic leukemia cells by superantigen-directed T cells.},
  author={Annacarin Wallgren and Roger Festin and C Gidl{\"o}f and Mikael Dohlsten and Terje Kalland and Thomas H. T{\"o}tterman},
  journal={Blood},
  year={1993},
  volume={82 4},
  pages={1230-8}
}
In vitro studies have indicated that chronic lymphocytic leukemia of B-cell origin (B-CLL) is resistant to cytotoxic effector lymphocytes such as natural killer and lymphokine activated killer (LAK) cells. We show here that B-cell cells are sensitive to Staphylococcal enterotoxin (SE) A-directed T-cell killing. Activation of the target cells by phorbol ester (tetradecanoyl phorbol acetate, [TPA]) greatly enhances their sensitivity to lysis. In SE-dependent cellular cytotoxicity (SDCC), members… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Stimulation of human naive and memory T helper cells with bacterial superantigen : Naive CD 4 + 45 RA + T cells require a costimulatory signal mediated through the LFA - l / ICAM - l pathway

  • T Yokochi, RD Holly, EA Clark
  • J Immunol
  • 1992

CD40 signaling activates CDI la/CD18 (LFA-])-mediated adhesion in B cells

  • EA Clark
  • J Immunol
  • 1991

Similar Papers

Loading similar papers…