Efficient isolation and quantitative proteomic analysis of cancer cell plasma membrane proteins for identification of metastasis-associated cell surface markers.

@article{Lund2009EfficientIA,
  title={Efficient isolation and quantitative proteomic analysis of cancer cell plasma membrane proteins for identification of metastasis-associated cell surface markers.},
  author={Rikke Raaen Lund and Rikke Leth-Larsen and Ole N\orregaard Jensen and Henrik J. Ditzel},
  journal={Journal of proteome research},
  year={2009},
  volume={8 6},
  pages={3078-90}
}
Cell surface membrane proteins are involved in central processes such as cell signaling, cell-cell interactions, ion and solute transport, and they seem to play a pivotal role in several steps of the metastatic process of cancer cells. The low abundance and hydrophobic nature of cell surface membrane proteins complicate their purification and identification by MS. We used two isogenic cell lines with opposite metastatic capabilities in nude mice to optimize cell surface membrane protein… CONTINUE READING

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