Efficient intraocular penetration of topical anti-TNF-alpha single-chain antibody (ESBA105) to anterior and posterior segment without penetration enhancer.

@article{Ottiger2009EfficientIP,
  title={Efficient intraocular penetration of topical anti-TNF-alpha single-chain antibody (ESBA105) to anterior and posterior segment without penetration enhancer.},
  author={Michael Ottiger and Michael A. Thiel and Ulrich Feige and Peter Lichtlen and David M. Urech},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 2},
  pages={779-86}
}
PURPOSE This study was designed to characterize ocular penetration pathways of ESBA105, a topically administered single-chain antibody (scFv) against tumor necrosis factor (TNF)-alpha, to the anterior and posterior segment of the eye. METHODS Fresh enucleated whole eyes and isolated corneas of rabbits mounted in perfusion chambers were used for ex vivo penetration studies. In vivo pharmacokinetics and ocular biodistribution of ESBA105 after intravitreal injection or topical administration as… CONTINUE READING
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