Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform.

  title={Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform.},
  author={L. C. Gomes-da-Silva and Y. Fern{\'a}ndez and I. Abasolo and S. Schwartz and Jos{\'e} S Ramalho and M. C. Pedroso de Lima and S. Sim{\~o}es and J. Moreira},
  volume={8 9},
  • L. C. Gomes-da-Silva, Y. Fernández, +5 authors J. Moreira
  • Published 2013
  • Medicine
  • Nanomedicine
  • AIM The design of novel F3-targeted liposomes with adequate features for systemic administration, to enable efficient intracellular delivery of siRNA toward both cancer and endothelial cells from angiogenic blood vessels. MATERIALS & METHODS Cellular association studies were performed by flow cytometry. Gene silencing was evaluated with eGFP-overexpressing cells, by flow cytometry and real-time reverse-transcription PCR. Safety and immunogenicity was assessed in CD1 mice. RESULTS A strong… CONTINUE READING
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