Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein.

@article{Gripon2005EfficientIO,
  title={Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein.},
  author={Philippe Gripon and Isabelle Cannie and Stephan Urban},
  journal={Journal of virology},
  year={2005},
  volume={79 3},
  pages={1613-22}
}
The lack of an appropriate in vitro infection system for the major human pathogen hepatitis B virus (HBV) has prevented a molecular understanding of the early infection events of HBV. We used the novel HBV-infectible cell line HepaRG and primary human hepatocytes to investigate the interference of infection by HBV envelope protein-derived peptides. We found that a peptide consisting of the authentically myristoylated N-terminal 47 amino acids of the pre-S1 domain of the large viral envelope… CONTINUE READING
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