Efficient inhibition of cathepsin B by a secreted type 1 cystatin of Fasciola gigantica.

@article{Siricoon2012EfficientIO,
  title={Efficient inhibition of cathepsin B by a secreted type 1 cystatin of Fasciola gigantica.},
  author={Sinee Siricoon and Suksiri Vichasri Grams and R. M. Grams},
  journal={Molecular and biochemical parasitology},
  year={2012},
  volume={186 2},
  pages={126-33}
}
Cysteine proteases are important antigens in the liver fluke genus Fasciola, essential for infection, protection and nutrition. While their biochemistry, biological roles and application as vaccines have been thoroughly studied there is a lack of data concerning their regulation. In the present study we have continued our investigation of cysteine protease inhibitors in Fasciola gigantica and demonstrate, in comparison with FgStefin-1 and human cystatin C, that a second type 1 cystatin of the… CONTINUE READING

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