Efficient infection of tree shrew (Tupaia belangeri) with hepatitis C virus grown in cell culture or from patient plasma.

@article{Xu2007EfficientIO,
  title={Efficient infection of tree shrew (Tupaia belangeri) with hepatitis C virus grown in cell culture or from patient plasma.},
  author={Xinping Xu and Hongbo Chen and Xiaomei Cao and Kun-long Ben},
  journal={The Journal of general virology},
  year={2007},
  volume={88 Pt 9},
  pages={2504-12}
}
The generation of a new, cost-effective, non-primate, small-animal model would greatly facilitate research into hepatitis C virus (HCV) pathogenesis and the development of novel therapeutic and preventative technologies to control the increasing HCV threat to public health. Native HCV from patient plasma and HCV grown in cell culture (HCVcc) were used to inoculate adult tree shrews. Each animal was inoculated with one HCV genotype. Alanine aminotransferase (ALT) levels, HCV RNA and viral load… CONTINUE READING

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