Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors.

@article{Yu2003EfficientIO,
  title={Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors.},
  author={Aixin Yu and Jiehao Zhou and Norman W. Marten and Cornelia C. Bergmann and Michele Mammolenti and Robert H. Levy and Thomas R Malek},
  journal={Journal of immunology},
  year={2003},
  volume={170 1},
  pages={236-42}
}
IL-2 and IL-15 are thought to be important cytokines for T cell-dependent immune responses. Mice deficient in IL-2, IL-2Ralpha, and IL-2Rbeta are each characterized by a rapid lethal autoimmune lymphoproliferative disorder that complicates their use in studies aimed at investigating the role of these cytokines and receptors for immune responses in vivo. We have previously characterized a novel transgenic (Tg) mouse on the IL-2Rbeta-/- genetic background (Tg-/- mice) that lacks autoimmune… CONTINUE READING
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