Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck.

@article{Stoytcheva2006EfficientIO,
  title={Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck.},
  author={Zoia R Stoytcheva and Rosa M Tujebajeva and John W. Harney and Marla J. Berry},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 24},
  pages={9177-84}
}
Selenocysteine is incorporated into proteins via "recoding" of UGA from a stop codon to a sense codon, a process that requires specific secondary structures in the 3' untranslated region, termed selenocysteine incorporation sequence (SECIS) elements, and the protein factors that they recruit. Whereas most selenoprotein mRNAs contain a single UGA codon and a single SECIS element, selenoprotein P genes encode multiple UGAs and two SECIS elements. We have identified evolutionary adaptations in… CONTINUE READING
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