Efficient in vivo gene transfer into the heart in the rat myocardial infarction model using the HVJ (Hemagglutinating Virus of Japan)--liposome method.

@article{Aoki1997EfficientIV,
  title={Efficient in vivo gene transfer into the heart in the rat myocardial infarction model using the HVJ (Hemagglutinating Virus of Japan)--liposome method.},
  author={Masashi Aoki and Ryuichi Morishita and Akihiko Muraishi and Atsushi Moriguchi and Tsutomu Sugimoto and Keiko Maeda and Victor J. Dzau and Yasufumi Kaneda and Jituo Higaki and Toshio Ogihara},
  journal={Journal of molecular and cellular cardiology},
  year={1997},
  volume={29 3},
  pages={949-59}
}
The lack of efficient treatment for myocardial infarction remains an unresolved problem in the field of cardiovascular disease. Gene therapy may be a potential therapeutic strategy for the treatment of myocardial infarction. However, current methods of in vivo gene transfer into the heart are limited by their low efficiency and/or potential toxicity. In the present study, we developed an efficient technique of gene transfer into the intact heart in vivo using the Sendai virus (HVJ… CONTINUE READING
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