Efficient homologous prime-boost strategies for T cell vaccination based on virus-like particles.

@article{Schwarz2005EfficientHP,
  title={Efficient homologous prime-boost strategies for T cell vaccination based on virus-like particles.},
  author={Katrin Schwarz and Edwin Meijerink and Daniel E Speiser and Alain C. Tissot and Indulis Cielens and Regina Renhof and Andris Dishlers and Paul Pumpens and M F Bachmann},
  journal={European journal of immunology},
  year={2005},
  volume={35 3},
  pages={816-21}
}
Induction of high frequencies of specific T cells by vaccination requires prime-boost regimens. To reach optimal immune responses, it is necessary to use different vectors for priming and boosting as e.g. DNA vaccination followed by boosting with a recombinant viral vector. Here, we show that vaccines based on virus-like particles (VLP) displaying peptide epitopes are equally effective to induce CTL responses if used in a homologous or heterologous prime-boost setting. Strikingly, high… CONTINUE READING

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