Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector.

@article{Whitelaw2004EfficientGO,
  title={Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector.},
  author={Christopher Bruce Alexander Whitelaw and Pippa A. Radcliffe and William A. Ritchie and Ailsa Carlisle and Fiona Margaret Ellard and Ramona N Pena and Jacob M. Rowe and Alvin J. Clark and Tim King and Kyriacos A. Mitrophanous},
  journal={FEBS letters},
  year={2004},
  volume={571 1-3},
  pages={
          233-6
        }
}
Traditional methods of transgene delivery in livestock are inefficient. Recently, human immunodeficiency virus (HIV-1) based lentiviral vectors have been shown to offer an efficient transgene delivery system. We now extend this method by demonstrating efficient generation of transgenic pigs using an equine infectious anaemia virus derived vector. We used this vector to deliver a green fluorescent protein expressing transgene; 31% of injected/transferred eggs resulted in a transgenic founder… CONTINUE READING
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