Efficient generation of human T cells from a tissue-engineered thymic organoid

  title={Efficient generation of human T cells from a tissue-engineered thymic organoid},
  author={Mark C. Poznansky and Richard H. Evans and Russell B Foxall and Ivona T. Olszak and Anita H. Piascik and Kelly Hartman and C. E. Brander and Thomas P H Meyer and Mark J. Pykett and Karissa T. Chabner and Spyros A. Kalams and Michael B. Rosenzweig and David T Scadden},
  journal={Nature Biotechnology},
Biocompatible inorganic matrices have been used to enhance bone repair by integrating with endogenous bone architecture. Hypothesizing that a three-dimensional framework might support reconstruction of other tissues as well, we assessed the capacity of a tantalum-coated carbon matrix to support reconstitution of functioning thymic tissue. We engineered a thymic organoid by seeding matrices with murine thymic stroma. Co-culture of human bone marrow-derived hematopoietic progenitor cells within… CONTINUE READING


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T - cell receptor alpha locus V ( D ) J recombination by - products are abundant in thymocytes and mature T cells

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