Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells

@article{Song2009EfficientGO,
  title={Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells},
  author={Zhihua Song and Jun Peng Cai and Yanxia Liu and Dongxin Zhao and Jun Yow Yong and Shuguang Duo and Xijun Song and Yushan Guo and Yang Zhao and Han Wen Qin and Xiaolei Yin and Chen Wu and Jie Che and S C Lu and Mingxiao Ding and Hongkui Deng},
  journal={Cell Research},
  year={2009},
  volume={19},
  pages={1233-1242}
}
Human induced pluripotent stem (iPS) cells are similar to embryonic stem (ES) cells, and can proliferate intensively and differentiate into a variety of cell types. However, the hepatic differentiation of human iPS cells has not yet been reported. In this report, human iPS cells were induced to differentiate into hepatic cells by a stepwise protocol. The expression of liver cell markers and liver-related functions of the human iPS cell-derived cells were monitored and compared with that of… CONTINUE READING
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