Efficient generation of astrocytes from human pluripotent stem cells in defined conditions.

@article{Shaltouki2013EfficientGO,
  title={Efficient generation of astrocytes from human pluripotent stem cells in defined conditions.},
  author={Atossa Shaltouki and Jun Peng and Qiuyue Liu and Mahendra S. Rao and Xianmin Zeng},
  journal={Stem cells},
  year={2013},
  volume={31 5},
  pages={941-52}
}
Astrocytes can be generated from various tissue sources including human pluripotent stem cells (PSC). In this manuscript, we describe a chemically defined xeno-free medium culture system for rapidly generating astrocytes from neural stem cells derived from PSC. We show that astrocyte development in vitro, mimics normal development in vivo, and also passes through a CD44(+) astrocyte precursor stage. Astrocytes generated by our method display similar gene expression patterns, morphological… CONTINUE READING
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