Efficient generation of antigen-specific CTLs by the BAFF-activated human B Lymphocytes as APCs: a novel approach for immunotherapy

@inproceedings{Yiwen2016EfficientGO,
  title={Efficient generation of antigen-specific CTLs by the BAFF-activated human B Lymphocytes as APCs: a novel approach for immunotherapy},
  author={Zhang Yiwen and Gao Shilin and Chen Yingshi and Su Lishi and Luo Baohong and Liu Chao and Li Linghua and Pan Ting and Zhang Hui},
  booktitle={Oncotarget},
  year={2016}
}
Efficient antigen presentation is indispensable for cytotoxic T lymphocyte (CTL)-mediated immunotherapy. B-lymphocytes propagated with CD40L have been developed as antigen-presenting cells (APCs), but this capacity needs further optimization. Here, we aimed to expand human B-lymphocytes on a large scale while maintaining their antigen-presenting ability by using both CD40L and B-cell activating factor (BAFF). The addition of BAFF enhanced the expansion efficiency and prolonged the culture time… CONTINUE READING

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