Efficient gene transfer into retinal cells using adenoviral vectors: dependence on receptor expression.

@article{Mallam2004EfficientGT,
  title={Efficient gene transfer into retinal cells using adenoviral vectors: dependence on receptor expression.},
  author={Joshua N Mallam and Mary Y. Hurwitz and Timothy R. Mahoney and Patricia Ch{\'e}vez-Barrios and Richard L. Hurwitz},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 6},
  pages={1680-7}
}
PURPOSE A number of ocular diseases are potentially amenable to gene therapy interventions if appropriate vectors for the targeted administration of therapeutic genes can be identified. In vitro and in vivo transduction efficiency of a Group C serotype 5 adenoviral vector containing the fiber domain derived from a Group B serotype 35 adenovirus and the gene encoding green fluorescent protein (AdV5/F35-GFP) was compared to an AdV5-GFP vector for transgene delivery to human retinoblastoma and to… CONTINUE READING
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