Efficient gene transfer into human monocyte-derived macrophages using defective lentiviral vectors.

@article{Lu2003EfficientGT,
  title={Efficient gene transfer into human monocyte-derived macrophages using defective lentiviral vectors.},
  author={Yuanan Lu and Chun-Chi Liu and Ling-bing Zeng and Zhi Lin and Stephen M. Dewhurst and Suzanne Gartner and Vicente Planelles},
  journal={Cellular and molecular biology},
  year={2003},
  volume={49 7},
  pages={1151-6}
}
Gene therapy is a promising approach for the treatment of neurological disorders. However, current approaches to gene transfer in the central nervous system (CNS) are limited by the lack of effective, but non-invasive methods to deliver transgenes across the blood-brain barrier (BBB). In an effort to begin to explore the use of migratory monocytes as vehicles for delivery of therapeutic and antiviral genes into the CNS, we have utilized three HIV-based transfer vectors encoding cis-acting… CONTINUE READING