Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors

@article{Rahim2009EfficientGD,
  title={Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors},
  author={Ahad A Rahim and Andrew M. S. Wong and Steven J Howe and Suzanne M. K. Buckley and Alejandro Acosta-Saltos and K E Elston and Natalie J. Ward and Nicola J. Philpott and Jon D. Cooper and Patrick Anderson and Simon N Waddington and Adrian J. Thrasher and Gennadij Raivich},
  journal={Gene Therapy},
  year={2009},
  volume={16},
  pages={509-520}
}
Non-integrating lentiviral vectors show considerable promise for gene therapy applications as they persist as long-term episomes in non-dividing cells and diminish risks of insertional mutagenesis. In this study, non-integrating lentiviral vectors were evaluated for their use in the adult and fetal central nervous system of rodents. Vectors differentially pseudotyped with vesicular stomatitis virus, rabies and baculoviral envelope proteins allowed targeting of varied cell populations. Efficient… CONTINUE READING
48 Citations
31 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Similar Papers

Loading similar papers…