Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.

@article{Chen2006EfficientGD,
  title={Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.},
  author={Shuyuan Chen and Jia-huan Ding and Raffi Bekeredjian and Bing-zhi Yang and Ralph V. Shohet and Stephen A. Johnston and Hans Ewald Hohmeier and Christopher B. Newgard and Paul Artur Grayburn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 22},
  pages={8469-74}
}
This study describes a method of gene delivery to pancreatic islets of adult, living animals by ultrasound targeted microbubble destruction (UTMD). The technique involves incorporation of plasmids into the phospholipid shell of gas-filled microbubbles, which are then infused into rats and destroyed within the pancreatic microcirculation with ultrasound. Specific delivery of genes to islet beta cells by UTMD was achieved by using a plasmid containing a rat insulin 1 promoter (RIP), and reporter… CONTINUE READING

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