Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.

@article{Asai2010EfficientFC,
  title={Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.},
  author={Masashi Asai and Nobuhisa Iwata and Taisuke Tomita and Takeshi Iwatsubo and Shoichi Ishiura and Takaomi C Saido and Kei Maruyama},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 16},
  pages={3588-97}
}
Cocktail treatment is an effective multidrug medication therapy for some diseases, such as cancer and AIDS, because of the additive or synergistic effect of each medicine and relief from adverse effects. Amyloid-β peptide (Aβ), which is now recognized as central to the development of Alzheimer's disease (AD), is derived from the sequential proteolysis of amyloid precursor protein (APP) by β- and γ-secretases. Secretase inhibitors are one of most attractive targets for therapeutic intervention… CONTINUE READING
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Alzheimer’s disease

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  • Lancet
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Highly Influential
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