Efficient foreign gene expression in Epstein-Barr virus-transformed human B-cells.

@article{Curiel1994EfficientFG,
  title={Efficient foreign gene expression in Epstein-Barr virus-transformed human B-cells.},
  author={Tyler Jay Curiel and Daniel M. Cook and C. Bogedain and Wolfgang Jilg and G. S. Harrison and M Cotten and David T. Curiel and Ernst Wagner},
  journal={Virology},
  year={1994},
  volume={198 2},
  pages={577-85}
}
Epstein-Barr virus (EBV) is a herpesvirus that transforms B-cells (B-LCL) and has undergone intense scrutiny owing to its association with Burkitt's lymphoma, nasopharyngeal carcinoma, and immunoblastic lymphomas. B-LCL have also proven useful in the study of human immunology. We describe a novel system for inducing efficient foreign gene expression in B-LCL using biotinylated adenovirus as an endosome-disrupting agent. Plasmid DNA is coupled to the exterior of viral particles by streptavidin… CONTINUE READING

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