Efficient episomal reprogramming of blood mononuclear cells and differentiation to hepatocytes with functional drug metabolism.

@article{Liu2015EfficientER,
  title={Efficient episomal reprogramming of blood mononuclear cells and differentiation to hepatocytes with functional drug metabolism.},
  author={Jing Liu and Joanna Brzeszczyńska and Kay Samuel and Jim Black and Anwar Azad Palakkan and Richard A. Anderson and Ronald C J Gallagher and James Alexander Ross},
  journal={Experimental cell research},
  year={2015},
  volume={338 2},
  pages={203-13}
}
The possibility of converting cells from blood mononuclear cells (MNC) to liver cells provides promising opportunities for the study of diseases and the assessment of new drugs. However, clinical applications have to meet GMP requirements and the methods for generating induced pluripotent cells (iPCs) have to avoid insertional mutagenesis, a possibility… CONTINUE READING