Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury.

@article{Kerr2010EfficientDO,
  title={Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury.},
  author={Candace Kerr and Brian S. Letzen and Christine Hill and Gracee Agrawal and Nitish V. Thakor and Jared L Sterneckert and John D. Gearhart and Angelo H. All},
  journal={The International journal of neuroscience},
  year={2010},
  volume={120 4},
  pages={305-13}
}
This study utilized a contusion model of spinal cord injury (SCI) in rats using the standardized NYU-MASCIS impactor, after which oligodendrocyte progenitor cells (OPCs) derived from human embryonic stem cell (ESC) were transplanted into the spinal cord to study their survival and migration route toward the areas of injury. One critical aspect of successful cell-based SCI therapy is the time of injection following injury. OPCs were injected at two clinically relevant times when most damage… CONTINUE READING
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Oligodendrocyte origins

  • R. H. Miller
  • Trends in Neurosciences,
  • 1996
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