Efficient diagnosis of tuberculous meningitis by detection of Mycobacterium tuberculosis DNA in cerebrospinal fluid filtrates using PCR.

@article{Haldar2009EfficientDO,
  title={Efficient diagnosis of tuberculous meningitis by detection of Mycobacterium tuberculosis DNA in cerebrospinal fluid filtrates using PCR.},
  author={Sagarika Haldar and Neera Sharma and Vikash Kr Gupta and Jaya Sivaswami Tyagi},
  journal={Journal of medical microbiology},
  year={2009},
  volume={58 Pt 5},
  pages={616-24}
}
Tuberculous meningitis (TBM) is the most devastating form of meningitis and prompt diagnosis holds the key to its management. Conventional microbiology has limited utility and nucleic acid-based methods have not been widely accepted for various reasons. In view of the paucibacillary nature of cerebrospinal fluid (CSF) and the recent demonstration of free Mycobacterium tuberculosis DNA in clinical specimens, the present study was designed to evaluate the utility of CSF 'filtrates' for the… CONTINUE READING
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