Efficient derivation of microglia-like cells from human pluripotent stem cells

@inproceedings{Muffat2016EfficientDO,
  title={Efficient derivation of microglia-like cells from human pluripotent stem cells},
  author={Julien Muffat and Y. L. Li and Bingbing Yuan and Maisam Mitalipova and Attya Omer and Sean Corcoran and Grisilda Bakiasi and Li-Huei Tsai and Patrick A Aubourg and Richard M Ransohoff and Rudolf Jaenisch},
  booktitle={Nature Medicine},
  year={2016}
}
Microglia, the only lifelong resident immune cells of the central nervous system (CNS), are highly specialized macrophages that have been recognized to have a crucial role in neurodegenerative diseases such as Alzheimer's, Parkinson's and adrenoleukodystrophy (ALD). However, in contrast to other cell types of the human CNS, bona fide microglia have not yet been derived from cultured human pluripotent stem cells. Here we establish a robust and efficient protocol for the rapid production of… CONTINUE READING
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