Efficient derivation of lateral plate and paraxial mesoderm subtypes from human embryonic stem cells through GSKi-mediated differentiation.

@article{Tan2013EfficientDO,
  title={Efficient derivation of lateral plate and paraxial mesoderm subtypes from human embryonic stem cells through GSKi-mediated differentiation.},
  author={Jia Yong Tan and Gopu Sriram and Abdul Jalil Rufaihah and Koon Gee Neoh and Tong Cao},
  journal={Stem cells and development},
  year={2013},
  volume={22 13},
  pages={1893-906}
}
The vertebrae mesoderm is a source of cells that forms a variety of tissues, including the heart, vasculature, and blood. Consequently, the derivation of various mesoderm-specific cell types from human embryonic stem cells (hESCs) has attracted the interest of many investigators owing to their therapeutic potential in clinical applications. However, the need for efficient and reliable methods of differentiation into mesoderm lineage cell types remains a significant challenge. Here, we… CONTINUE READING
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