Efficient delivery of nucleic acid molecules into skin by combined use of microneedle roller and flexible interdigitated electroporation array

@inproceedings{Huang2018EfficientDO,
  title={Efficient delivery of nucleic acid molecules into skin by combined use of microneedle roller and flexible interdigitated electroporation array},
  author={Dong Huang and Deyao Zhao and Xiaoxia Wang and Chunhui Li and Tongren Yang and Lili Du and Zewen Wei and Q. Cheng and Huiqing Cao and Zicai Liang and Yuanyu Huang and Zhihong Li},
  booktitle={Theranostics},
  year={2018}
}
Rationale: Delivery of nucleic acid molecules into skin remains a main obstacle for various types of gene therapy or vaccine applications. Here we propose a novel electroporation approach via combined use of a microneedle roller and a flexible interdigitated electroporation array (FIEA) for efficient delivery of DNA and siRNA into mouse skin. Methods: Using micromachining technology, closely spaced gold electrodes were made on a pliable parylene substrate to form a patch-like electroporation… CONTINUE READING

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