Efficient delivery of intact phosphodiester oligonucleotides by poly-beta-amino esters.

@article{Remaut2010EfficientDO,
  title={Efficient delivery of intact phosphodiester oligonucleotides by poly-beta-amino esters.},
  author={Katrien Remaut and Nathalie Symens and Bart Lucas and Joseph Demeester and Stefaan C. De Smedt},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2010},
  volume={144 1},
  pages={65-74}
}
Due to their great instability, phosphodiester antisense oligonucleotides (PO-ODNs) are rapidly degraded in the intracellular environment, which limits their biological activity. The release of PO-ODNs during a prolonged period of time could however greatly enhance their antisense effect by creating a pool of intact PO-ODNs at any time point. Poly-beta-aminoesters are biodegradable cationic polymers which show potential for the controlled release of short DNA fragments like ODNs and small… CONTINUE READING

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