Efficient degradation and expression prioritization with small RNAs.

  title={Efficient degradation and expression prioritization with small RNAs.},
  author={Namiko Mitarai and Anna M. C. Andersson and Sandeep Krishna and Szabolcs Semsey and Kim Sneppen},
  journal={Physical biology},
  volume={4 3},
We build a simple model for feedback systems involving small RNA (sRNA) molecules based on the iron metabolism system in the bacterium E. coli, and compare it with the corresponding system in H. pylori which uses purely transcriptional regulation. This reveals several unique features of sRNA-based regulation that could be exploited by cells. Firstly, we show that sRNA regulation can maintain a smaller turnover of target mRNAs than transcriptional regulation, without sacrificing the speed of… CONTINUE READING

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Efficient Degradation and Expression Prioritization with Small RNAs 15 the Helicobacter pylori Fur regulatory circuit by genome - wide location analysis

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