Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G


The AID/APOBEC family of enzymes in higher vertebrates converts cytosines in DNA or RNA to uracil. They play a role in antibody maturation and innate immunity against viruses, and have also been implicated in the demethylation of DNA during early embryogenesis. This is based in part on reported ability of activation-induced deaminase (AID) to deaminate 5… (More)
DOI: 10.1093/nar/gks685


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