Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles.

  title={Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles.},
  author={Mi Yang and Honglin Jin and Juan B. Chen and Lili Ding and Kenneth K. W. Ng and Qiaoya Lin and Jonathan F Lovell and Zhihong Zhang and Gang Zheng},
  volume={7 5},
and encapsulation into lipid nanoparticles. [ 7 ] Therapeutic application of RNA interference (RNAi) requires delivery of siRNAs into the cytoplasm of targeted cells and tissues, where they are recognized and associated with RNA-induced silencing complex (RISC) to perform their function. [ 8 ] This rate-limiting delivery step has been dealt with by several approaches, such as co-encapsulation of fusogenic lipid [ 9 ] or fusogenic peptide, [ 10 ] liposomal bubbles and ultrasound, [ 11 ]