Efficient control of Leishmania and Strongyloides despite partial suppression of nematode-induced Th2 response in co-infected mice.

@article{Kolbaum2011EfficientCO,
  title={Efficient control of Leishmania and Strongyloides despite partial suppression of nematode-induced Th2 response in co-infected mice.},
  author={Julia Kolbaum and Uwe Ritter and Nicole Zimara and Nancy Brewig and M-L Eschbach and Minka Breloer},
  journal={Parasite immunology},
  year={2011},
  volume={33 4},
  pages={226-35}
}
Endemic regions for the pathogenic nematode Strongyloides and parasitic protist Leishmania overlap and therefore co-infections with both parasites frequently occur. As the Th2 and Th1 immune responses necessary to efficiently control Strongyloides and Leishmania infections are known to counterregulate each other, we analysed the outcome of co-infection in the murine system. Here, we show that Leishmania major-specific Th1 responses partially suppressed the nematode-induced Th2 response in co… CONTINUE READING

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