Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain

@article{Miller1986EfficientCS,
  title={Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain},
  author={Jim Miller and Ronald N. Germain},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={164},
  pages={1478 - 1489}
}
The intracytoplasmic forms of class II (or Ia) major histocompatibility complex heterodimers are associated with a third glycoprotein, termed the invariant chain (Ii). This specific interaction has led to the view that Ii plays a necessary role in the assembly, intracellular transport, and/or membrane insertion of Ia molecules. To test this hypothesis directly, we have transfected complementary DNA clones that encode murine class II alpha and beta chains into cells that do not express any… CONTINUE READING

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