Efficient catalysts for asymmetric Mannich reactions.


Efficient chiral catalysts for direct asymmetric three-component Mannich reactions of ketones, aldehydes and an amine (p-anisidine) have been developed. The corresponding β-amino carbonyl compounds (Mannich adducts) were obtained in good chemical yields and excellent enantio- and diastereoselectivities. The reaction conditions have been optimized by… (More)
DOI: 10.1039/c3ob40681d


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@article{Rachwalski2013EfficientCF, title={Efficient catalysts for asymmetric Mannich reactions.}, author={Michał Rachwalski and T J M Leenders and Sylwia Kaczmarczyk and Piotr Kiełbasiński and Stanisław Leśniak and Floris P J T Rutjes}, journal={Organic & biomolecular chemistry}, year={2013}, volume={11 25}, pages={4207-13} }