Efficient asymmetric synthesis of structurally diverse P-stereogenic phosphinamides for catalyst design.

Abstract

The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a general, efficient, and highly enantioselective method for the synthesis of structurally diverse P-stereogenic phosphinamides. The method relies on nucleophilic substitution of a chiral phosphinate… (More)
DOI: 10.1002/anie.201500350

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