Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis.

Abstract

A concise, stereospecific synthesis of radicicol dimethyl ether is presented. The strategy relies on a convergent three-stage assembly of the 14-membered lactone which has, as a key transformation, a novel ring-forming metathesis reaction utilizing a vinyl epoxide.

Cite this paper

@article{Garbaccio2000EfficientAS, title={Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis.}, author={Robert M Garbaccio and S J Danishefsky}, journal={Organic letters}, year={2000}, volume={2 20}, pages={3127-9} }