Efficient asymmetric synthesis of chiral amines by combining transaminase and pyruvate decarboxylase.

@article{Hhne2008EfficientAS,
  title={Efficient asymmetric synthesis of chiral amines by combining transaminase and pyruvate decarboxylase.},
  author={Matthias H{\"o}hne and Steffen K{\"u}hl and Karen T Robins and Uwe T Bornscheuer},
  journal={Chembiochem : a European journal of chemical biology},
  year={2008},
  volume={9 3},
  pages={363-5}
}
Chiral amines and amino acids play an important role in the pharmaceutical, agrochemical and chemical industry. They are frequently used as synthons for the preparation of various pharmaceutically active substances and agrochemicals, or as resolving agents for chiral acids. Consequently, there is a need for efficient methods to obtain the desired R or S enantiomer in an optically pure form. The most frequently used enzymatic method for the production of optically active amines is the kinetic… CONTINUE READING