Efficient antibacterial agents: a review of the synthesis, biological evaluation and mechanism of pleuromutilin derivatives.

Pleuromutilins were discovered as natural-product antibiotics in 1950. The modifications of pleuromutilin lead to the successful development of veterinary medicines such as tiamulin and valnemulin. Retapamulin became the first pleuromutilin approved for use in human skin infections. Recent advances have led to the synthesis of pleuromutilins that combine… CONTINUE READING