Efficient and isoform-selective inhibition of cellular gene expression by peptide nucleic acids.

@article{Liu2004EfficientAI,
  title={Efficient and isoform-selective inhibition of cellular gene expression by peptide nucleic acids.},
  author={Yinghui Liu and Dwaine A. Braasch and Christopher J. Nulf and David R. Corey},
  journal={Biochemistry},
  year={2004},
  volume={43 7},
  pages={
          1921-7
        }
}
Peptide nucleic acids (PNAs) are a potentially powerful approach for the recognition of cellular mRNA and the inhibition of gene expression. Despite their promise, the rules for using antisense PNAs have remained obscure, and antisense PNAs have been used sparingly in research. Here we investigate the ability of PNAs to be effective antisense agents inside mammalian cells, to inhibit expression of human caveolin-1 (hCav-1), and to discriminate between its alpha and beta isoforms. Many human… CONTINUE READING
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