Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

@article{Haracska2000EfficientAA,
  title={Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η},
  author={Lajos Haracska and S L Yu and Robert E. Johnson and L. T. Om Prakash and Satya Prakash},
  journal={Nature Genetics},
  year={2000},
  volume={25},
  pages={458-461}
}
Oxidative damage to DNA has been proposed to have a role in cancer and ageing. Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA, and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the adducts formed. Eukaryotic replicative DNA polymerases replicate DNA containing 8-oxoG by inserting an adenine opposite the lesion; consequently, 8-oxoG is highly mutagenic and causes G:C to T:A transversions. Genetic studies in yeast have indicated a role for mismatch repair… CONTINUE READING

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