Efficient and accurate causal inference with hidden confounders from genome-transcriptome variation data

Abstract

Mapping gene expression as a quantitative trait using whole genome-sequencing and transcriptome analysis allows to discover the functional consequences of genetic variation. We developed a novel method and ultra-fast software Findr for higly accurate causal inference between gene expression traits using cis-regulatory DNA variations as causal anchors, which… (More)
DOI: 10.1371/journal.pcbi.1005703

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