Efficient algorithms to discover alterations with complementary functional association in cancer

@article{Basso2018EfficientAT,
  title={Efficient algorithms to discover alterations with complementary functional association in cancer},
  author={R. S. Basso and D. Hochbaum and Fabio Vandin},
  journal={PLoS Computational Biology},
  year={2018},
  volume={15}
}
  • R. S. Basso, D. Hochbaum, Fabio Vandin
  • Published 2018
  • Computer Science, Biology, Medicine
  • PLoS Computational Biology
  • Recent large cancer studies have measured somatic alterations in an unprecedented number of tumours. These large datasets allow the identification of cancer-related sets of genetic alterations by identifying relevant combinatorial patterns. Among such patterns, mutual exclusivity has been employed by several recent methods that have shown its effectiveness in characterizing gene sets associated to cancer. Mutual exclusivity arises because of the complementarity, at the functional level, of… CONTINUE READING

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